Systematic Reviewmoderate evidence
Turning back time: a comprehensive list of interventions that decrease next-generation epigenetic aging clocks in humans.
Frontiers in genetics·January 1, 2026·PMID 42294499
Why it mattersNext-generation epigenetic clocks are more strongly linked to all-cause mortality than earlier versions, making them potential surrogate markers for evaluating anti-aging interventions. This review aggregates evidence across diverse therapies, helping clinicians and researchers identify which interventions may influence biological aging and warrant further investigation or cautious integration into longevity-focused care.
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