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Population-scale reconstruction of menopause dynamics reveals a physiological cliff at the final menstrual period.
Nature medicine·October 1, 2026·PMID 42864411
Why it mattersMenopause is typically viewed as a gradual transition, but this large-scale analysis reveals abrupt, multi-system physiological shifts at the final menstrual period. Recognizing this 'cliff' can help clinicians anticipate and monitor accelerated changes in bone, liver, kidney, and lipid profiles, and may inform timing of interventions such as hormone therapy.
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