Cohort Studyhigh evidence
Brain gray matter changes across chronic pain trajectories: MRI evidence from 35,000 individuals.
Pain·October 2, 2026·PMID 42825605
Why it mattersChronic pain is common and disabling, yet the reversibility of associated brain structural changes has been unclear. This study provides robust evidence that most gray matter alterations reflect adaptive neuroplasticity rather than irreversible damage or preexisting vulnerability, reinforcing the value of effective pain treatment for brain health.
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