Randomized Trialhigh evidence
Gabapentin for Pain Management after Major Surgery: A Placebo-controlled, Double-blinded, Randomized Clinical Trial (the GAP Study).
Anesthesiology·October 1, 2025·PMID 40663783
Why it mattersGabapentin is widely used off-label in perioperative multimodal analgesia despite limited evidence in major surgery. This large, high-quality trial provides robust data that routine gabapentin does not improve recovery or safety in these patients.
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