Intradiscal linezolid (PP353) treatment for chronic low back pain associated with Modic change type 1: an international, first-in-human, randomised, sham procedure-controlled, double-blind, phase 1b clinical trial.

EClinicalMedicine·February 1, 2026·PMID 41768986

Why it matters

For clinicians managing refractory chronic low back pain with Modic changes, this study tests a targeted intradiscal antibiotic strategy rather than prolonged oral therapy. It suggests a possible minimally invasive option for a biologically selected subgroup, but the evidence remains early-phase.