Randomized Trialhigh evidence
Efficacy of lemborexant on sleep quality and neurocognitive outcomes among hospital rotating shift workers: A randomized, double-blind, placebo-controlled trial.
Sleep medicine·October 1, 2026·PMID 42284966
Why it mattersRotating shift work disrupts circadian rhythms and sleep, impairing cognition and increasing inflammation. This study provides evidence that a dual orexin receptor antagonist can improve sleep, cognitive function, and inflammatory profiles in this high-risk population, which is relevant for clinicians managing shift workers' health and performance.
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