Randomized Trialhigh evidence
Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study.
Critical care (London, England)·August 18, 2026·PMID 42618951
Why it mattersSpontaneous breathing trial selection remains controversial because PSV and T-piece have different physiological effects. This study characterizes a third option—tracheal HFO—showing it can maintain lung recruitment and oxygenation without increasing inspiratory effort, potentially offering a more physiological bridge to extubation.
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