Randomized Trialhigh evidence
Pulse versus Nonpulse Corticosteroid Therapy in Acute Exacerbation of Idiopathic Pulmonary Fibrosis: A Multicenter, Randomized Clinical Trial (SAFER).
American journal of respiratory and critical care medicine·September 30, 2026·PMID 42813947
Why it mattersAE-IPF carries high short-term mortality, yet corticosteroid dosing is not standardized. This trial provides direct evidence that pulse-dose methylprednisolone offers no survival advantage over a lower-dose regimen, informing dosing decisions in critical care and internal medicine.
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