Cohort Studyhigh evidence
Association Between Testosterone Replacement Therapy and Prostatic Disorders in Elderly Hypogonadal Men.
The Journal of clinical endocrinology and metabolism·February 20, 2026·PMID 40922669
Why it mattersConcerns about prostate cancer risk often deter TRT use in older hypogonadal men. These real-world data suggest TRT is not associated with increased prostate cancer risk and may even be protective, while modestly raising BPH risk—information that can guide more nuanced risk-benefit discussions.
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