Studymoderate evidence
Mendelian randomization investigation into testosterone's trade-offs between longevity and reproductive fitness.
The aging male : the official journal of the International Society for the Study of the Aging Male·December 31, 2026·PMID 42608999
Why it mattersTestosterone's role in trade-offs between reproductive success and longevity is central to understanding aging and hormone therapy risks. These findings suggest that higher testosterone in men may carry a survival cost despite reproductive benefits, informing discussions about testosterone supplementation and long-term health.
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