Randomized Trialhigh evidence
Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial.
Lancet (London, England)·July 25, 2026·PMID 42413523
Why it mattersThis is the first adequately powered RCT to compare anticoagulation strategies in ECMO, addressing a critical evidence gap. It suggests that less aggressive anticoagulation may reduce bleeding without increasing thrombotic risk, potentially improving outcomes in a high-stakes ICU population.
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