Randomized Trialhigh evidence
Intravenous Patient-Controlled Analgesia Versus Oral Opioids to Maintain Analgesia for Severe Cancer Pain: A Randomized Phase III Trial.
Journal of the National Comprehensive Cancer Network : JNCCN·May 12, 2026·PMID 42119607
Why it mattersSevere cancer pain often requires rapid, effective titration. This trial validates that IV PCA hydromorphone offers superior analgesia to oral morphine and that a simpler bolus-only regimen can match continuous infusion efficacy with less opioid exposure, informing safer, effective inpatient protocols.
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