Randomized Trialvery high evidence
Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity.
The New England journal of medicine·August 14, 2025·PMID 40544433
Why it mattersThis trial provides high-quality evidence for a novel dual agonist combination that achieves weight loss approaching that of bariatric surgery, expanding pharmacotherapy options for obesity management.

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