Randomized Trialhigh evidence
Biologically enhanced anterior cruciate ligament reconstruction: Platelet-rich plasma or bone marrow aspirate concentrate does not lead to better clinical or radiological outcomes-A randomized controlled trial of 175 cases with 2 years of follow-up.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·June 19, 2026·PMID 42319381
Why it mattersBiologic augmentation with PRP or BMAC is widely used in ACLR despite limited high-level evidence. This Level I trial suggests no clinical or radiological benefit, and potential harm with BMAC, helping surgeons avoid ineffective or costly interventions.
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