Randomized Trialhigh evidence

Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.

JAMA·September 16, 2026·PMID 42747844

Why it matters

Asymptomatic carotid stenosis is linked to cognitive decline, and revascularization is sometimes considered for cognitive benefit. These robust randomized data clarify that neither stenting nor endarterectomy improves cognition beyond medical management, informing patient counseling and avoiding unnecessary procedures for cognitive indications.

Infographic summary of Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.
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