Basic Sciencemoderate evidence
Exercise enhances aged chondrocyte health through microRNA-29-enriched extracellular vesicles.
Nature aging·October 1, 2026·PMID 42811122
Why it mattersCartilage degeneration in aging and osteoarthritis lacks effective disease-modifying therapies. This paper identifies a specific molecular pathway—exercise-induced microRNA-29 in EVs—that promotes chondrocyte health and cartilage integrity. For clinicians in orthopedics, aging, and regenerative medicine, it offers a mechanistic basis for exercise as a therapeutic intervention and a potential target for EV-based therapies.
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