Randomized Trialhigh evidence
Intra-articular platelet-rich plasma demonstrates superior clinical and serum biomarker outcomes compared with corticosteroids and NSAIDs in late-stage knee osteoarthritis: a randomised controlled trial.
Journal of orthopaedic surgery and research·June 2, 2026·PMID 42231445
Why it mattersLate-stage knee OA patients have limited non-surgical options. This study provides evidence that PRP may offer meaningful pain relief and functional improvement while reducing opioid consumption and positively influencing disease-related biomarkers, potentially serving as a bridge therapy before joint replacement.
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