Cohort Studyhigh evidence
Origins and impact of extrachromosomal DNA.
Nature·November 1, 2024·PMID 39506150
Why it mattersecDNA is a key driver of treatment resistance and poor outcomes in cancer. This large-scale analysis clarifies its prevalence, tissue-specific patterns, and immune-modulatory roles, helping oncologists understand why some tumors evade therapy and suggesting ecDNA as a potential biomarker for aggressive disease.
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