Randomized Trialhigh evidence
Treatment of knee osteoarthritis with a single injection of autologous micro-fragmented adipose tissue is not superior to a placebo saline injection: a blinded randomised controlled trial with 2-year follow-up.
British journal of sports medicine·August 26, 2025·PMID 40101939
Why it mattersMicro-fragmented adipose tissue is a popular regenerative therapy for knee OA, but this high-quality trial shows it offers no benefit over saline injection. Specialists should reconsider its use and counsel patients that observed improvements may be due to placebo or natural history.
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