Randomized Trialhigh evidence
Prolotherapy versus epidural steroid injections for lumbar pain with associated leg pain: A pragmatic randomized controlled trial.
PM & R : the journal of injury, function, and rehabilitation·April 29, 2026·PMID 42053118
Why it mattersESI is a common but often limited treatment for lumbar radicular pain. This trial suggests prolotherapy may offer superior long-term pain relief and functional improvement, providing an evidence-based alternative for interventional pain specialists.
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