Randomized Trialhigh evidence

Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial.

JAMA psychiatry·January 1, 2025·PMID 39476073

Why it matters

This is the first large RCT to show that a combined CR and tDCS intervention can slow long-term cognitive decline in a high-risk population, offering a potential non-pharmacological strategy for prevention.

Infographic summary of Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial.
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