Randomized Trialhigh evidence
Randomized clinical trial comparing intra-articular injection of bone marrow aspirate clot and bone marrow aspirate concentrate in grade 3 and 4 knee osteoarthritis.
Stem cell research & therapy·April 29, 2026·PMID 42057095
Why it mattersFor clinicians using bone marrow-derived orthobiologics in advanced knee OA, this trial suggests the simpler, lower-cost BMA-clot approach may provide symptom and functional outcomes comparable to BMAC, without an apparent safety disadvantage over 12 months.
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