Cohort Studyhigh evidence
Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering.
Nature medicine·March 1, 2025·PMID 40011692
Why it mattersThe EC PRS identifies a subset of patients who are particularly sensitive to LDL-C and may gain outsized benefit from aggressive lipid lowering, offering a precision medicine tool to guide intensity of therapy beyond current risk stratification.
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