Reviewvery low evidence
Harnessing Endogenous Plasticity Rather than Reprogramming of Mature Cells Will Advance Regenerative Medicine, Cancer Treatment and Rejuvenation.
Stem cell reviews and reports·July 29, 2026·PMID 42527762
Why it mattersThe VSEL-centric model offers a paradigm shift for regenerative medicine, suggesting that harnessing endogenous stem cell niches could be more effective than reprogramming mature cells. This perspective could redirect therapeutic development toward niche restoration and away from dedifferentiation-based strategies.
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