Basic Sciencelow evidence
Endothelialized callus organoids drive rapid regeneration of critical-size segmental long bone defects.
Cell stem cell·September 3, 2026·PMID 42692019
Why it mattersCritical-size bone defects remain a major clinical challenge with limited effective treatments. This study demonstrates a novel organoid-based approach that recapitulates early fracture callus biology, offering a potential off-the-shelf regenerative strategy that leverages host healing mechanisms.
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