Cohort Studyhigh evidence
Long-term risk of depression after sevoflurane versus propofol anesthesia: a global propensity score-matched cohort study.
Translational psychiatry·May 14, 2026·PMID 42135318
Why it mattersAnesthesiologists and pain specialists frequently choose between sevoflurane and propofol. This study provides large-scale human evidence that anesthetic selection may influence long-term neuropsychiatric outcomes, potentially guiding agent choice in patients at risk for depression.
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