Cohort Studymoderate evidence
Comorbid insomnia and sleep apnea (COMISA) and incident cardiovascular risk: a prospective analysis from the HypnoLaus cohort.
EClinicalMedicine·October 1, 2026·PMID 42857102
Why it mattersIdentifying COMISA as a distinct high-risk phenotype could improve cardiovascular risk stratification and prompt targeted sleep interventions in patients with both conditions, who may otherwise be overlooked when each disorder is considered separately.
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