Cohort Studymoderate evidence
Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence.
Nature aging·November 1, 2024·PMID 39266768
Why it mattersIt identifies a specific cellular source of systemic aging and a druggable pathway, suggesting that targeting BMM-derived EVs or PPARα could mitigate age-related decline. The human data provide preliminary support for fenofibrate’s potential in promoting healthy longevity.
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