Randomized Trialhigh evidence
Sex-Specific Lipid, Apolipoprotein B, and Lipoprotein(a) Responses to Berberine Based on 2 Randomized Placebo-Controlled Trials.
JACC. Asia·July 11, 2026·PMID 42470424
Why it mattersLipid-lowering responses to nutraceuticals may differ by sex, yet this is rarely studied. Berberine’s greater efficacy in women for apoB and Lp(a) reduction, alongside divergent hormonal effects, highlights the need for sex-specific consideration when recommending complementary lipid therapies.
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