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Association Between Long-Term Testosterone Exposure and Major Adverse Cardiovascular Events in Aging Men.

Journal of the Endocrine Society·November 1, 2025·PMID 41163812

Why it matters

Testosterone therapy is commonly used for hypogonadism, but cardiovascular safety remains a key concern. This study provides real-world, long-term data suggesting increased MACE risk, which may inform risk-benefit discussions and monitoring strategies in aging men.

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