Randomized Trialhigh evidence
Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial.
JAMA·December 9, 2025·PMID 41159835
Why it mattersThis large, international RCT provides evidence that a structured, bedside physiology-guided resuscitation protocol using capillary refill time can reduce the burden of organ support in early septic shock, offering a practical, noninvasive approach to personalize hemodynamic management.
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