Randomized Trialhigh evidence

Efficacy and safety of the low-temperature-derived 3D printed biodegradable Mg-containing composite porous scaffold for bone defect repair: A prospective and multi-center randomized controlled trial.

Biomaterials·April 1, 2026·PMID 41106318

Why it matters

Critical-size bone defects remain challenging to treat. This first RCT on a low-temperature 3D-printed Mg-containing scaffold demonstrates accelerated early bone fusion and progressive scaffold integration, offering a potential new option for enhancing bone regeneration.

Infographic summary of Efficacy and safety of the low-temperature-derived 3D printed biodegradable Mg-containing composite porous scaffold for bone defect repair: A prospective and multi-center randomized controlled trial.
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