Systematic Reviewhigh evidence
Systematic Review of Pharmacologic Treatment for Migraine Prevention in Adults: Report of the AAN Guidelines Subcommittee and the American Headache Society.
Neurology·October 13, 2026·PMID 42673559
Why it mattersMigraine prevention remains challenging, with many patients not achieving adequate relief from existing options. This review consolidates high- and moderate-confidence evidence for both established and newer preventive medications, including CGRP monoclonal antibodies and gepants, across episodic and chronic migraine. It provides a current evidence base to guide treatment selection and supports the use of therapies that improve patient-reported quality of life.
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