Randomized Trialhigh evidence

Operating Room Air Filtration-Sterilization and Surgical Infections: The ORACLE Randomized Trial in 110,538 Surgeries.

Anesthesiology·October 19, 2026·PMID 42896234

Why it matters

Operating room air is a potential source of wound contamination, and supplemental air purification systems are marketed to reduce surgical infections. This large, blinded, cluster-randomized trial provides high-level evidence that such systems do not improve clinical outcomes, helping hospitals avoid ineffective expenditures and redirect infection-control resources.

Infographic summary of Operating Room Air Filtration-Sterilization and Surgical Infections: The ORACLE Randomized Trial in 110,538 Surgeries.
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