Randomized Trialhigh evidence
Polyphenols increase circulating lipids but improve LDL particle quality and reduce LDL oxidation in postmenopausal women: metabotype- and age-dependent effects in a randomised, placebo-controlled crossover trial.
European journal of nutrition·June 29, 2026·PMID 42371155
Why it mattersPostmenopausal women face heightened cardiometabolic risk, and polyphenols are widely used for cardiovascular health. This study clarifies that polyphenols may improve LDL quality and oxidative burden despite raising lipid concentrations, and that gut metabotypes strongly modulate these benefits, supporting personalized nutrition strategies.
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