Randomized Trialmoderate evidence
Metformin Preserves Regional Brain Glucose Uptake, Structure, and Functional Connectivity in Adults with Insulin Resistance.
The Journal of clinical investigation·October 27, 2026·PMID 42944764
Why it mattersInsulin resistance is a modifiable risk factor for dementia, but its neurobiological effects and reversibility are unclear. This study provides human imaging and cognitive evidence that metformin may preserve brain structure and function in older adults with IR, supporting insulin sensitization as a potential preventive strategy.
The papers that matter, first.
MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.
§
MedLit · Evidence, Distilled