Cohort Studyhigh evidence
Comorbidities, Weight-Based Initial Fluid Resuscitation, and Mortality in Patients With Sepsis.
JAMA network open·June 1, 2026·PMID 42284053
Why it mattersSepsis fluid resuscitation guidelines recommend ≥30 mL/kg, but clinicians often hesitate in patients with cardiac or kidney comorbidities or intermediate lactate elevation. This study provides real-world evidence supporting broader fluid administration in these subgroups, potentially reducing mortality.
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