Basic Sciencemoderate evidence
A glycolytic shunt via the pentose phosphate pathway is a metabolic checkpoint for nervous system sensory homeostasis and axonal regeneration.
Cell·February 19, 2026·PMID 41494529
Why it mattersCentral nervous system axons fail to regenerate, partly due to metabolic constraints. This study identifies the pentose phosphate pathway as a metabolic checkpoint that can be therapeutically targeted to promote repair after spinal cord injury.
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