Randomized Trialhigh evidence
Oxycodone combined with pulsed radiofrequency for refractory cancer pain from spinal metastases: a randomized controlled study.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·August 24, 2026·PMID 42635821
Why it mattersRefractory cancer pain from spinal metastases is challenging to manage, and opioid escalation carries significant side effects. Adding PRF to oxycodone may improve analgesia while reducing opioid burden and preserving immune function, which is relevant for oncologic outcomes.
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