Systematic Reviewmoderate evidence
Heterogeneity of Treatment Effect by Molecular Endotype in Acute Respiratory Distress Syndrome: A Systematic Review.
Annals of the American Thoracic Society·September 12, 2026·PMID 42730647
Why it mattersARDS trials have largely failed to identify effective therapies, possibly due to biological heterogeneity. This review clarifies which endotype-based subgroup effects are credible, helping critical care clinicians interpret post-hoc analyses and prioritize which endotype-guided approaches warrant prospective validation.
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