Cohort Studyhigh evidence
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
Nature aging·May 1, 2026·PMID 41974968
Why it mattersThe paper connects a feasible human lifestyle intervention with a specific innate immune pathway tied to aging-related inflammation. For clinicians interested in metabolic health and longevity, it identifies complement C3a as a plausible biomarker and therapeutic target, but the current evidence is mechanistic rather than outcomes-based.
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