Randomized Trialhigh evidence
Isoflurane-Based Inhaled Sedation in Mechanically Ventilated Adults With Acute Hypoxemic Respiratory Failure: The SAVE-ICU Randomized Clinical Trial.
JAMA·October 14, 2026·PMID 42872958
Why it mattersInhaled volatile sedation is increasingly used in ICUs, but rigorous outcome data are limited. This trial provides high-quality evidence that isoflurane-based sedation does not improve survival and may be associated with more rescue therapies for hypoxemia and less delirium-free time, informing sedation choices in severe respiratory failure.
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