Cohort Studyhigh evidence
Short-term survival of dual SGLT2i-MRA and four-class guideline-directed medical therapy in acute heart failure.
European journal of heart failure·July 22, 2026·PMID 42484006
Why it mattersDespite strong trial evidence, early GDMT initiation after acute heart failure remains underused. These real-world data reinforce that even partial GDMT—specifically SGLT2i plus MRA—is associated with substantial short-term survival benefit, providing a pragmatic target for discharge planning when full four-drug therapy is not immediately feasible.
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