Randomized Trialmoderate evidence
Effects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial.
Nutrients·August 27, 2026·PMID 42738972
Why it mattersObesity-related insulin resistance drives metabolic disease risk, and safe adjunctive options are needed. This trial provides moderate evidence that a specific nutraceutical combination can improve insulin sensitivity and body composition over 12 weeks, offering a potential adjunct for patients seeking non-pharmacologic support.
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