Cohort Studyhigh evidence

Varicella-zoster virus reactivation and the risk of dementia.

Nature medicine·December 1, 2025·PMID 41053450

Why it matters

Dementia prevention is a major public health priority. This study provides strong, large-scale evidence that herpes zoster vaccination may reduce dementia risk, offering a potential actionable intervention for clinicians managing older adults.

Infographic summary of Varicella-zoster virus reactivation and the risk of dementia.
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