Randomized Trialmoderate evidence
Reduced dietary protein intake does not alter autophagy in human blood: A randomized crossover study in healthy adults.
Clinical nutrition (Edinburgh, Scotland)·September 1, 2026·PMID 42721581
Why it mattersProtein restriction is widely promoted for longevity and metabolic health, yet human evidence on autophagy is scarce. This trial directly measures autophagic flux in blood and finds no effect from moderate protein reduction without caloric deficit, challenging assumptions that protein restriction alone activates autophagy in humans.
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