Cohort Studymoderate evidence
Pituitary Axis Impacts and Effectiveness of Clomiphene and Human Chorionic Gonadotropin in Treating Hypogonadism: Cohort Study.
The world journal of men's health·June 30, 2026·PMID 42402873
Why it mattersFor clinicians managing hypogonadism in men concerned about fertility, this study clarifies how different strategies affect pituitary hormones, which may guide treatment selection when preserving testicular function is a priority.

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