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Isocaloric switch from low-fat to Western high-fat diet triggers transcriptomic reprogramming and ectopic olfactory receptor responses.

Science advances·August 21, 2026·PMID 42616886

Why it matters

Even without weight gain, a Western diet rapidly reprograms adipose tissue and transiently worsens insulin resistance and inflammation, suggesting dietary composition alone can drive early metabolic risk.

Infographic summary of Isocaloric switch from low-fat to Western high-fat diet triggers transcriptomic reprogramming and ectopic olfactory receptor responses.
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