Randomized Trialhigh evidence
Differential Impacts of Methadone and Buprenorphine/Naloxone on Pain-Related Outcomes Among People With Non-Heroin Opioid Use Disorder: Secondary Analyses From a Pragmatic Canadian Multisite Trial.
Drug and alcohol review·July 1, 2026·PMID 42313747
Why it mattersClinicians managing patients with non-heroin opioid use disorder and comorbid pain need evidence to guide opioid agonist therapy selection. This study provides comparative data on analgesic effectiveness, informing shared decision-making when both addiction treatment and pain relief are goals.
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