Meta-Analysismoderate evidence
Impact of caloric restriction on biological aging: insights from a composite biomarker index in older adults.
GeroScience·September 12, 2026·PMID 42730911
Why it mattersBiological aging biomarkers are increasingly used to evaluate longevity interventions, but their responsiveness to caloric restriction in humans has been unclear. This analysis provides evidence that CR improves a composite index of aging-related biomarkers, and that the benefit is not solely due to weight loss, informing patient counseling and future trial design.
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